EL USO DEL MODELO FARMACOLÓGICO BASADO EN LA ADMINISTRACIÓN EXPERIMENTAL DE MK-801, PARA LA REVISIÓN Y RE-DEFINICIÓN DEL SISTEMA LÍMBICO EN EL CONTEXTO DE LA ANÁTOMO-PATOLOGÍA

Adrián Marcelo Bueno; Soledad de Olmos

doi:10.22235/cp.v3i1.140

Authors

Adrián Marcelo Bueno Universidad Nacional de Córdoba Universidad Católica de Córdoba INIMEC-CONICET
Soledad de Olmos INIMEC-CONICET

DOI:

https://doi.org/10.22235/cp.v3i1.140

Keywords:

MK-801, Neuronal death, Limbic System, Neuropathologic model

Abstract

The neuro-toxic effect induced in the rat limbic system after acute MK-801-treatment, affects all the limbic lobe areas, such as olfactory cortex, basolateral amygdala, hippocampal system, cingulate cortex and specific frontal and insular cortical region (allo-cortical and meso-cortical areas). In contrast, the sub-cortical nucleus usually included into the limbic system, such as the extended amygdala, the estriato-pallidal-ventral system, septal area, thalamus and hippothalamus, do not evidentiate neural death. Anatomo-pathological results suggest that the limbic lobe areas share common characteristics, and support the idea of a different functional unit, which differs from other sub-cortical “limbic” regions. This supports the idea of a limbic lobe formed only by thelencephalic allo-cortical and meso-cortical areas and implies the need to redefine the classic and broad concept of “limbic system”.

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